HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate → 1-((5-Chloro-6-(difluoromethoxy)pyridin-3-yl)methyl)-7-(2,6-dimethoxyphenyl)azepan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate | HCID 69082587 | — |
| Reactant | 3-Pyridinecarboxaldehyde, 5-chloro-6-(difluoromethoxy)- | HCID 86695614 | — |
| Product | 1-((5-Chloro-6-(difluoromethoxy)pyridin-3-yl)methyl)-7-(2,6-dimethoxyphenyl)azepan-2-one | HCID 69082359 | — |
Reaction Steps
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate with 5-chloro-6-(difluoromethoxy)nicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.94 min.; [M+H]+: 441.11 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-399b8c40ee3640b48429a43fdfdb6013 |
| Source note | uspto-grants-2016_01 |