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Dibenzo(b,d)furan-2-carboxaldehyde → 1-(Dibenzo[b,d]furan-2-ylmethyl)-7-(2,6-dimethoxyphenyl)azepan-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dibenzo(b,d)furan-2-carboxaldehyde | HCID 220843 | — |
| 反応物 | Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate | HCID 69082587 | — |
| 生成物 | 1-(Dibenzo[b,d]furan-2-ylmethyl)-7-(2,6-dimethoxyphenyl)azepan-2-one | HCID 69081081 | — |
反応手順
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate with commercially available dibenzo[b,d]furan-2-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions I): tR=1.53 min.; [M+H]+: 430.13 g/mol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09242970B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-98d301aeeff34de6beddf4b397abe0b0 |
| 出典メモ | uspto-grants-2016_01 |