Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate → 1-(3-(2H-1,2,3-triazol-2-yl)benzyl)-7-(2,6-dimethoxyphenyl)azepan-2-one

HRID 594519Notes

Reaction equation

HRID 594519 reaction equation
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=O.[N:21]1[N:22]([C:26]2[CH:27]=[C:28]([CH:31]=[CH:32][CH:33]=2)[CH:29]=O)[N:23]=[CH:24][CH:25]=1>>[N:21]1[N:22]([C:26]2[CH:27]=[C:28]([CH:31]=[CH:32][CH:33]=2)[CH2:29][N:1]2[CH:2]([C:11]3[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=3[O:19][CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]2=[O:9])[N:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 69082587Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoateHCID 834815283-(2H-1,2,3-triazol-2-yl)benzaldehyde

Product 1

HCID 690826991-(3-(2H-1,2,3-triazol-2-yl)benzyl)-7-(2,6-dimethoxyphenyl)azepan-2-one

Procedure

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate with 3-(2H-1,2,3-triazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.88 min.; [M+H]+: 407.09 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-b2e732de85e8446383ee9b1f9391934f
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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