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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594521Generated: October 30, 2026

Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate → 1-((2-(1H-pyrazol-1-yl)pyridin-4-yl)methyl)-7-(2,6-dimethoxyphenyl)azepan-2-one

https://huagongshe.com/reaction/594521

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoateHCID 69082587—
ReactantHCID 86695613HCID 86695613—
Product1-((2-(1H-pyrazol-1-yl)pyridin-4-yl)methyl)-7-(2,6-dimethoxyphenyl)azepan-2-oneHCID 69084538—

Reaction Steps

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate with 2-(1H-pyrazol-1-yl)isonicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.83 min.; [M+H]+: 407.11 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-933d876c156c49c6977df1716f8227a4
Source noteuspto-grants-2016_01