HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-3-(pyridin-2-yl)benzaldehyde → 7-(2,6-Dimethoxyphenyl)-1-(4-fluoro-3-(pyridin-2-yl)benzyl)azepan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-3-(pyridin-2-yl)benzaldehyde | HCID 63681157 | — |
| Reactant | Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate | HCID 69082587 | — |
| Product | 7-(2,6-Dimethoxyphenyl)-1-(4-fluoro-3-(pyridin-2-yl)benzyl)azepan-2-one | HCID 69084632 | — |
Reaction Steps
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate with 4-fluoro-3-(pyridin-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.74 min.; [M+H]+: 435.13 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-befb81f8a4c74edaa03c14ccfac5f0f1 |
| Source note | uspto-grants-2016_01 |