4-(Trifluoromethoxy)benzylamine → HCID 69085197, compound

HRID 594526Notes

Reaction equation

HRID 594526 reaction equation
O=[C:2]([C:9]1[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[CH:11][C:10]=1[O:19][CH3:20])[CH2:3][CH2:4][C:5]([O:7]C)=O.[F:21][C:22]([F:33])([F:32])[O:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][NH2:31])=[CH:26][CH:25]=1>>[F:21][C:22]([F:32])([F:33])[O:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][N:31]2[CH:2]([C:9]3[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[CH:11][C:10]=3[O:19][CH3:20])[CH2:3][CH2:4][C:5]2=[O:7])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 61645017HCID 61645017, compound

Product 1

HCID 69085197HCID 69085197, compound

Procedure

Prepared according to the described general procedure 3 (GP3) by reaction of methyl 4-oxo-4-(2,4,6-trimethoxyphenyl)butanoate with commercially available (4-(trifluoromethoxy)phenyl)methanamine. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions D): tR=1.08 min.; [M+H]+: 425.72 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-62580efc9749457197669badf3577f5b
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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