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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594542Generated: October 30, 2026

3-(1,3-Thiazol-2-yl)benzaldehyde → 5-(2,6-Dimethoxyphenyl)-1-(3-(thiazol-2-yl)benzyl)pyrrolidin-2-one

https://huagongshe.com/reaction/594542

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(1,3-Thiazol-2-yl)benzaldehydeHCID 18525725—
ReactantMethyl 4-amino-4-(2,6-dimethoxyphenyl)butanoateHCID 69082397—
Product5-(2,6-Dimethoxyphenyl)-1-(3-(thiazol-2-yl)benzyl)pyrrolidin-2-oneHCID 69082685—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of methyl 4-amino-4-(2,6-dimethoxyphenyl)butanoate with commercially available 3-(thiazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.79 min.; [M+H]+: 395.12 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-0efd8183b65b4b298683c2f31e78125c
Source noteuspto-grants-2016_01