HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Piperidinobenzaldehyde → 5-(2,6-Dimethoxyphenyl)-1-(3-(piperidin-1-yl)benzyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Piperidinobenzaldehyde | HCID 7164587 | — |
| Reactant | Methyl 4-amino-4-(2,6-dimethoxyphenyl)butanoate | HCID 69082397 | — |
| Product | 5-(2,6-Dimethoxyphenyl)-1-(3-(piperidin-1-yl)benzyl)pyrrolidin-2-one | HCID 69083442 | — |
Reaction Steps
Prepared according to the described general procedure 2 (GP2) by reaction of methyl 4-amino-4-(2,6-dimethoxyphenyl)butanoate with commercially available 3-(piperidin-1-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.57 min.; [M+H]+: 394.99 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-12d7c02c61104935a8bd7917cd72bf55 |
| Source note | uspto-grants-2016_01 |