1-Phenyl-1H-pyrazole-4-carbaldehyde → 5-(2,6-dimethoxyphenyl)-3-methyl-1-((1-phenyl-1H-pyrazol-4-yl)methyl)pyrrolidin-2-one

HRID 594562노트

반응식

HRID 594562 반응식
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH:4]([CH3:10])[C:5]([O:7]CC)=O.[C:21]1([N:27]2[CH:31]=[C:30]([CH:32]=O)[CH:29]=[N:28]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH3:18][O:17][C:16]1[CH:15]=[CH:14][CH:13]=[C:12]([O:19][CH3:20])[C:11]=1[CH:2]1[N:1]([CH2:32][C:30]2[CH:29]=[N:28][N:27]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:31]=2)[C:5](=[O:7])[CH:4]([CH3:10])[CH2:3]1

참가 물질

3

반응물 2

HCID 9520891-Phenyl-1H-pyrazole-4-carbaldehydeHCID 69085588Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate

생성물 1

HCID 866956465-(2,6-dimethoxyphenyl)-3-methyl-1-((1-phenyl-1H-pyrazol-4-yl)methyl)pyrrolidin-2-one

실험 절차

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with commercially available 1-phenyl-1H-pyrazole-4-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.81 min.; [M+H]+: 392.03 g/mol.

후처리

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

출처 및 근거

ORD 기록
ord-331404e623804b91b117ade92e542c38
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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