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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594564Generated: October 29, 2026

Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate → 5-(2,6-Dimethoxyphenyl)-1-(2-fluoro-3-(pyridin-2-yl)benzyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594564

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoateHCID 69085588—
Reactant2-Fluoro-3-(pyridin-2-yl)benzaldehydeHCID 86695608—
Product5-(2,6-Dimethoxyphenyl)-1-(2-fluoro-3-(pyridin-2-yl)benzyl)-3-methylpyrrolidin-2-oneHCID 69085719—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with 2-fluoro-3-(pyridin-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.68 min.; [M+H]+: 421.11 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-c092dea63655484885da02f5e4da89f7
Source noteuspto-grants-2016_01