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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594566Generated: October 30, 2026

3-(5-Methylthiazol-2-yl)benzaldehyde → 5-(2,6-Dimethoxyphenyl)-3-methyl-1-(3-(5-methylthiazol-2-yl)benzyl)pyrrolidin-2-one

https://huagongshe.com/reaction/594566

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(5-Methylthiazol-2-yl)benzaldehydeHCID 53273723—
ReactantEthyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoateHCID 69085588—
Product5-(2,6-Dimethoxyphenyl)-3-methyl-1-(3-(5-methylthiazol-2-yl)benzyl)pyrrolidin-2-oneHCID 69085705—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with 3-(5-methylthiazol-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.89 min.; [M+H]+: 423.09 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-c591a9b8e1874235838f0de2d93f783d
Source noteuspto-grants-2016_01