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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594573Generated: October 30, 2026

6-(1H-Pyrazol-1-yl)-2-pyridinecarboxaldehyde → 1-((6-(1H-pyrazol-1-yl)pyridin-2-yl)methyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594573

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(1H-Pyrazol-1-yl)-2-pyridinecarboxaldehydeHCID 10511407—
ReactantEthyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoateHCID 69085588—
Product1-((6-(1H-pyrazol-1-yl)pyridin-2-yl)methyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-oneHCID 69085718—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with 6-(1H-pyrazol-1-yl)picolinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.80 min.; [M+H]+: 393.10 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-13c8c0222cb04f739c3e920bfc92ab58
Source noteuspto-grants-2016_01