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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594575Generated: October 26, 2026

4-Fluorobenzyl bromide → 6-(2,6-Dimethoxyphenyl)-1-(4-fluorobenzyl)piperidin-2-one

https://huagongshe.com/reaction/594575

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluorobenzyl bromideHCID 68021—
Reactant6-(2,6-Dimethoxyphenyl)piperidin-2-oneHCID 69082526—
Product6-(2,6-Dimethoxyphenyl)-1-(4-fluorobenzyl)piperidin-2-oneHCID 69082195—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with commercially available 1-(bromomethyl)-4-fluorobenzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.73 min.; [M+H]+: 344.22 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-09214e5b74444422a5864699ac3ae05b
Source noteuspto-grants-2016_01