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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594576Generated: October 26, 2026

1-(Bromomethyl)-4-chlorobenzene → 1-(4-Chlorobenzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

https://huagongshe.com/reaction/594576

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-chlorobenzeneHCID 69329—
Reactant6-(2,6-Dimethoxyphenyl)piperidin-2-oneHCID 69082526—
Product1-(4-Chlorobenzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-oneHCID 69084650—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with commercially available 1-(bromomethyl)-4-chlorobenzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.77 min.; [M+H]+: 360.18 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-a409e304ede4472296a0ceb6835d642d
Source noteuspto-grants-2016_01