HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyloxybenzyl chloride → 6-(2,6-Dimethoxyphenyl)-1-(4-methoxybenzyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| Reactant | 6-(2,6-Dimethoxyphenyl)piperidin-2-one | HCID 69082526 | — |
| Product | 6-(2,6-Dimethoxyphenyl)-1-(4-methoxybenzyl)piperidin-2-one | HCID 69083632 | — |
Reaction Steps
Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with commercially available 1-(chloromethyl)-4-methoxybenzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.72 min.; [M+H]+: 356.26 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-d4de9a6b243b4af48781f2cc7481079f |
| Source note | uspto-grants-2016_01 |