4-(Trifluoromethylthio)benzyl bromide → HCID 69081835, compound

HRID 594580Notes

Reaction equation

HRID 594580 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[NH:16][C:15](=[O:17])[CH2:14][CH2:13][CH2:12]1.Br[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([S:26][C:27]([F:30])([F:29])[F:28])=[CH:22][CH:21]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[N:16]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([S:26][C:27]([F:30])([F:28])[F:29])=[CH:22][CH:21]=2)[C:15](=[O:17])[CH2:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 27778824-(Trifluoromethylthio)benzyl bromideHCID 690825266-(2,6-Dimethoxyphenyl)piperidin-2-one

Product 1

HCID 69081835HCID 69081835, compound

Procedure

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with commercially available (4-(bromomethyl)phenyl)(trifluoromethyl)sulfane. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.83 min.; [M+H]+: 426.20 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-a22177b3cfb5420a9775f87f7e789254
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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