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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594583Generated: October 26, 2026

4-(Difluoromethoxy)benzyl Bromide → 1-(4-(Difluoromethoxy)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

https://huagongshe.com/reaction/594583

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Difluoromethoxy)benzyl BromideHCID 2737001—
Reactant6-(2,6-Dimethoxyphenyl)piperidin-2-oneHCID 69082526—
Product1-(4-(Difluoromethoxy)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-oneHCID 69083818—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with commercially available 1-(bromomethyl)-4-(difluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.76 min.; [M+H]+: 392.16 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-7669c33055844c8d883197dbd54eecbf
Source noteuspto-grants-2016_01