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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594585Generated: October 30, 2026

1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 6-(4-Chloro-2,6-dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)piperidin-2-one

https://huagongshe.com/reaction/594585

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 142785—
Reactant6-(4-Chloro-2,6-dimethoxyphenyl)piperidin-2-oneHCID 69085048—
Product6-(4-Chloro-2,6-dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)piperidin-2-oneHCID 69083597—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(4-chloro-2,6-dimethoxyphenyl)piperidin-2-one with commercially available 1-(bromomethyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.84 min.; [M+H]+: 444.09 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-dc5829e8db7d46dd934ca5cc710b404d
Source noteuspto-grants-2016_01