1-[4-(Bromomethyl)phenyl]-1H-pyrrole → HCID 69081376, compound

HRID 594587Notes

Reaction equation

HRID 594587 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[NH:16][C:15](=[O:17])[CH2:14][CH2:13][CH2:12]1.Br[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]2[CH:30]=[CH:29][CH:28]=[CH:27]2)=[CH:22][CH:21]=1>>[N:26]1([C:23]2[CH:24]=[CH:25][C:20]([CH2:19][N:16]3[CH:11]([C:4]4[C:5]([O:9][CH3:10])=[CH:6][CH:7]=[CH:8][C:3]=4[O:2][CH3:1])[CH2:12][CH2:13][CH2:14][C:15]3=[O:17])=[CH:21][CH:22]=2)[CH:27]=[CH:28][CH:29]=[CH:30]1

Participants

3

Reactant 2

HCID 27954561-[4-(Bromomethyl)phenyl]-1H-pyrroleHCID 690825266-(2,6-Dimethoxyphenyl)piperidin-2-one

Product 1

HCID 69081376HCID 69081376, compound

Procedure

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with commercially available 1-(4-(bromomethyl)phenyl)-1H-pyrrole. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.80 min.; [M+H]+: 391.18 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-ebab68dc426d449b8fed07dbb718deac
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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