2-(Chloromethyl)-6-methoxynaphthalene → HCID 69085773, compound

HRID 594589Notes

Reaction equation

HRID 594589 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[NH:16][C:15](=[O:17])[CH2:14][CH2:13][CH2:12]1.Cl[CH2:19][C:20]1[CH:29]=[CH:28][C:27]2[C:22](=[CH:23][CH:24]=[C:25]([O:30][CH3:31])[CH:26]=2)[CH:21]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[N:16]([CH2:19][C:20]2[CH:29]=[CH:28][C:27]3[C:22](=[CH:23][CH:24]=[C:25]([O:30][CH3:31])[CH:26]=3)[CH:21]=2)[C:15](=[O:17])[CH2:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 133842572-(Chloromethyl)-6-methoxynaphthaleneHCID 690825266-(2,6-Dimethoxyphenyl)piperidin-2-one

Product 1

HCID 69085773HCID 69085773, compound

Procedure

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with 2-(chloromethyl)-6-methoxynaphthalene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.80 min.; [M+H]+: 406.18 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-902afb76463141c9961864d8d2b257a3
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

Loading…