1-(Bromomethyl)-4-(trifluoromethoxy)benzene → HCID 69085032, compound

HRID 594590Notes

Reaction equation

HRID 594590 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[C:5]([O:11][CH3:12])[C:4]=1[CH:13]1[NH:18][C:17](=[O:19])[CH2:16][CH2:15][CH2:14]1.Br[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][C:29]([F:32])([F:31])[F:30])=[CH:24][CH:23]=1>>[F:30][C:29]([F:31])([F:32])[O:28][C:25]1[CH:26]=[CH:27][C:22]([CH2:21][N:18]2[CH:13]([C:4]3[C:3]([O:2][CH3:1])=[CH:8][C:7]([O:9][CH3:10])=[CH:6][C:5]=3[O:11][CH3:12])[CH2:14][CH2:15][CH2:16][C:17]2=[O:19])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 69083548HCID 69083548, compound

Product 1

HCID 69085032HCID 69085032, compound

Procedure

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,4,6-trimethoxyphenyl)piperidin-2-one with commercially available 1-(bromomethyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions D): tR=1.10 min.; [M+H]+: 439.78 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-9dd4e9a9d6b74ea3aae2296612e736a1
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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