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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594591Generated: October 28, 2026

1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 6-(2,6-Dimethoxyphenyl)-4-methyl-1-(4-(trifluoromethoxy)benzyl)piperidin-2-one

https://huagongshe.com/reaction/594591

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 142785—
Reactant6-(2,6-Dimethoxyphenyl)-4-methylpiperidin-2-oneHCID 69085401—
Product6-(2,6-Dimethoxyphenyl)-4-methyl-1-(4-(trifluoromethoxy)benzyl)piperidin-2-oneHCID 76332238—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)-4-methylpiperidin-2-one with commercially available 1-(bromomethyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions D): tR=1.13 min.; [M+H]+: 423.91 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-d2191863bd74423ea8d3c8a7c5b21edf
Source noteuspto-grants-2016_01