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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594594Generated: October 30, 2026

1-(Bromomethyl)-4-(2-fluoroethoxy)benzene → 6-(2,6-Dimethoxyphenyl)-1-(4-(2-fluoroethoxy)benzyl)piperidin-2-one

https://huagongshe.com/reaction/594594

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(2-fluoroethoxy)benzeneHCID 15671413—
Reactant6-(2,6-Dimethoxyphenyl)piperidin-2-oneHCID 69082526—
Product6-(2,6-Dimethoxyphenyl)-1-(4-(2-fluoroethoxy)benzyl)piperidin-2-oneHCID 86695648—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with 1-(bromomethyl)-4-(2-fluoroethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions F): tR=0.80 min.; [M+H]+: 388.23 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-8b4fd3ecaafa4007864397e8116ee647
Source noteuspto-grants-2016_01