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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594596Generated: October 30, 2026

3-(Difluoromethoxy)benzyl bromide → 1-(3-(Difluoromethoxy)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

https://huagongshe.com/reaction/594596

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Difluoromethoxy)benzyl bromideHCID 2736999—
Reactant6-(2,6-Dimethoxyphenyl)piperidin-2-oneHCID 69082526—
Product1-(3-(Difluoromethoxy)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-oneHCID 69082216—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with commercially available 1-(bromomethyl)-3-(difluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions D): tR=1.05 min.; [M+H]+: 392.75 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-c3ae65b4a0f24b1c9dfe0b53411510e6
Source noteuspto-grants-2016_01