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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594601Generated: October 30, 2026

Pyridine, 2-(bromomethyl)-6-(difluoromethoxy)- → 1-((6-(Difluoromethoxy)pyridin-2-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

https://huagongshe.com/reaction/594601

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyridine, 2-(bromomethyl)-6-(difluoromethoxy)-HCID 69082287—
Reactant6-(2,6-Dimethoxyphenyl)piperidin-2-oneHCID 69082526—
Product1-((6-(Difluoromethoxy)pyridin-2-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-oneHCID 69084628—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with 2-(bromomethyl)-6-(difluoromethoxy)pyridine. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.83 min.; [M+H]+: 393.19 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-05d1f327449246c996d86a920616a0a7
Source noteuspto-grants-2016_01