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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594604Generated: October 31, 2026

Benzene, 1-(1-bromopropyl)-4-(trifluoromethoxy)- → 6-(2,6-Dimethoxyphenyl)-1-(1-(4-(trifluoromethoxy)phenyl)propyl)piperidin-2-one

https://huagongshe.com/reaction/594604

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzene, 1-(1-bromopropyl)-4-(trifluoromethoxy)-HCID 53466431—
Reactant6-(2,6-Dimethoxyphenyl)piperidin-2-oneHCID 69082526—
Product6-(2,6-Dimethoxyphenyl)-1-(1-(4-(trifluoromethoxy)phenyl)propyl)piperidin-2-oneHCID 69085323—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with 1-(1-bromopropyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.99 min.; [M+H]+: 438.22 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-f2543697f63b4004a92909ffd6160dd1
Source noteuspto-grants-2016_01