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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594606Generated: November 3, 2026

2-(Bromomethyl)-4-(difluoromethoxy)pyridine → 1-((4-(Difluoromethoxy)pyridin-2-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

https://huagongshe.com/reaction/594606

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Bromomethyl)-4-(difluoromethoxy)pyridineHCID 69080160—
Reactant6-(2,6-Dimethoxyphenyl)piperidin-2-oneHCID 69082526—
Product1-((4-(Difluoromethoxy)pyridin-2-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-oneHCID 69084014—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with 2-(bromomethyl)-4-(difluoromethoxy)pyridine. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.61 min.; [M+H]+: 393.12 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-fbb0f0ca347d44e1a00e5a0de3d50e23
Source noteuspto-grants-2016_01