HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Bromomethyl)biphenyl → 1-([1,1'-Biphenyl]-3-ylmethyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Bromomethyl)biphenyl | HCID 3864405 | — |
| Reactant | 6-(2,6-Dimethoxyphenyl)piperidin-2-one | HCID 69082526 | — |
| Product | 1-([1,1'-Biphenyl]-3-ylmethyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one | HCID 69081873 | — |
Reaction Steps
Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with commercially available 3-(bromomethyl)-1,1′-biphenyl. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.95 min.; [M+H]+: 402.16 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-cd550b4de31c4e4aa596498c95dc8a3c |
| Source note | uspto-grants-2016_01 |