1-(Bromomethyl)-4-(trifluoromethoxy)benzene → HCID 69080890, compound

HRID 594611Notes

Reaction equation

HRID 594611 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[NH:17][C:16](=[O:18])[CH2:15][CH2:14][CH2:13][CH2:12]1.Br[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[N:17]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]([F:29])([F:30])[F:31])=[CH:23][CH:22]=2)[C:16](=[O:18])[CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 69083770HCID 69083770, compound

Product 1

HCID 69080890HCID 69080890, compound

Procedure

Prepared according to the described general procedure 4 (GP4) by reaction of 7-(2,6-dimethoxyphenyl)azepan-2-one with commercially available 1-(bromomethyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.98 min.; [M+H]+: 424.20 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-11697369b4ed4aa7abbbfedc4c2858e2
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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