4-Fluorobenzyl bromide → 5-(2-Ethoxyphenyl)-1-(4-fluorobenzyl)pyrrolidin-2-one

HRID 594612Notes

Reaction equation

HRID 594612 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]1[NH:14][C:13](=[O:15])[CH2:12][CH2:11]1)[CH3:2].Br[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]1[N:14]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[C:13](=[O:15])[CH2:12][CH2:11]1)[CH3:2]

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 690824815-(2-Ethoxyphenyl)pyrrolidin-2-one

Product 1

HCID 690845775-(2-Ethoxyphenyl)-1-(4-fluorobenzyl)pyrrolidin-2-one

Procedure

Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2-ethoxyphenyl)pyrrolidin-2-one with commercially available 1-(bromomethyl)-4-fluorobenzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions D): tR=1.01 min.; [M+H]+: 313.99 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-450fc878c54f4f44816ffde959e5005c
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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