HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzyl bromide → 5-(2,6-Dimethoxyphenyl)-1-(4-fluorobenzyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzyl bromide | HCID 68021 | — |
| Reactant | 5-(2,6-Dimethoxyphenyl)pyrrolidin-2-one | HCID 69080911 | — |
| Product | 5-(2,6-Dimethoxyphenyl)-1-(4-fluorobenzyl)pyrrolidin-2-one | HCID 69085756 | — |
Reaction Steps
Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)pyrrolidin-2-one with commercially available 1-(bromomethyl)-4-fluorobenzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.71 min.; [M+H]+: 330.24 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-12aed9d020874c699f39475e1f7b47d3 |
| Source note | uspto-grants-2016_01 |