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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594616Generated: October 31, 2026

3-(Difluoromethoxy)benzyl bromide → 1-(3-(Difluoromethoxy)benzyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594616

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Difluoromethoxy)benzyl bromideHCID 2736999—
Reactant5-(2,6-Dimethoxyphenyl)-3-methylpyrrolidin-2-oneHCID 69080143—
Product1-(3-(Difluoromethoxy)benzyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-oneHCID 69081700—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one with commercially available 1-(bromomethyl)-3-(difluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions F): tR=0.84 min.; [M+H]+: 392.16 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-bec32741c6f749298ce646339823a9fa
Source noteuspto-grants-2016_01