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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594618Generated: October 30, 2026

1-(Bromomethyl)-3-(trifluoromethoxy)benzene → 5-(2,6-Dimethoxyphenyl)-3-methyl-1-(3-(trifluoromethoxy)benzyl)pyrrolidin-2-one

https://huagongshe.com/reaction/594618

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-3-(trifluoromethoxy)benzeneHCID 737176—
Reactant5-(2,6-Dimethoxyphenyl)-3-methylpyrrolidin-2-oneHCID 69080143—
Product5-(2,6-Dimethoxyphenyl)-3-methyl-1-(3-(trifluoromethoxy)benzyl)pyrrolidin-2-oneHCID 69081309—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one with commercially available 1-(bromomethyl)-3-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.93 min.; [M+H]+: 410.18 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-f05bf35f97a44085bfa32787cab9c540
Source noteuspto-grants-2016_01