HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(2,6-Dimethoxyphenyl)-3-methylpyrrolidin-2-one → 1-((6-(Difluoromethoxy)pyridin-2-yl)methyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(2,6-Dimethoxyphenyl)-3-methylpyrrolidin-2-one | HCID 69080143 | — |
| Reactant | Pyridine, 2-(bromomethyl)-6-(difluoromethoxy)- | HCID 69082287 | — |
| Product | 1-((6-(Difluoromethoxy)pyridin-2-yl)methyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one | HCID 86695650 | — |
Reaction Steps
Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one with 2-(bromomethyl)-6-(difluoromethoxy)pyridine. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.84 min.; [M+H]+: 393.19 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-e68fbabc611a4e1a96cc17363187ee33 |
| Source note | uspto-grants-2016_01 |