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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594620Generated: October 31, 2026

5-(2,6-Dimethoxyphenyl)-3-methylpyrrolidin-2-one → 1-((2-(Difluoromethoxy)pyridin-4-yl)methyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594620

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(2,6-Dimethoxyphenyl)-3-methylpyrrolidin-2-oneHCID 69080143—
Reactant4-(Bromomethyl)-2-(difluoromethoxy)pyridineHCID 69082503—
Product1-((2-(Difluoromethoxy)pyridin-4-yl)methyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-oneHCID 86695651—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one with 4-(bromomethyl)-2-(difluoromethoxy)-pyridine. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.83 min.; [M+H]+: 393.19 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-e1b9e4a6fc354a71be9222197382c00f
Source noteuspto-grants-2016_01