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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594622Generated: October 30, 2026

5-(2,6-Dimethoxyphenyl)-3-methylpyrrolidin-2-one → 1-((4-(Difluoromethoxy)pyridin-2-yl)methyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594622

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(2,6-Dimethoxyphenyl)-3-methylpyrrolidin-2-oneHCID 69080143—
Reactant2-(Bromomethyl)-4-(difluoromethoxy)pyridineHCID 69080160—
Product1-((4-(Difluoromethoxy)pyridin-2-yl)methyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-oneHCID 86695652—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one with 2-(bromomethyl)-4-(difluoromethoxy)pyridine. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.67 min.; [M+H]+: 393.08 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-105ed54273fa47e8af9f19272f49eb0c
Source noteuspto-grants-2016_01