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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594623Generated: October 31, 2026

Ethyl Bromide → 6-(2,6-Dimethoxyphenyl)-1-(4-ethoxybenzyl)piperidin-2-one

https://huagongshe.com/reaction/594623

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl BromideHCID 6332—
Reactant6-(2,6-Dimethoxyphenyl)-1-(4-hydroxybenzyl)piperidin-2-oneHCID 69081744—
Product6-(2,6-Dimethoxyphenyl)-1-(4-ethoxybenzyl)piperidin-2-oneHCID 69084076—

Reaction Steps

Prepared according to the described general procedure 7 (GP7) by O-alkylation of 6-(2,6-dimethoxyphenyl)-1-(4-hydroxybenzyl)piperidin-2-one with commercially available bromoethane. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.76 min.; [M+H]+: 370.17 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-63c30aba54f5437c9f70e66a62b0d64a
Source noteuspto-grants-2016_01