HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopropane → 6-(2,6-Dimethoxyphenyl)-1-(4-isopropoxybenzyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopropane | HCID 6358 | — |
| Reactant | 6-(2,6-Dimethoxyphenyl)-1-(4-hydroxybenzyl)piperidin-2-one | HCID 69081744 | — |
| Product | 6-(2,6-Dimethoxyphenyl)-1-(4-isopropoxybenzyl)piperidin-2-one | HCID 69081348 | — |
Reaction Steps
Prepared according to the described general procedure 7 (GP7) by O-alkylation of 6-(2,6-dimethoxyphenyl)-1-(4-hydroxybenzyl)piperidin-2-one with commercially available 2-bromopropane. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.77 min.; [M+H]+: 384.28 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-7f2ee1d45e3b4adfae9db1ffc8b82d60 |
| Source note | uspto-grants-2016_01 |