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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594625Generated: October 31, 2026

1-Bromopropane → 6-(2,6-Dimethoxyphenyl)-1-(4-propoxybenzyl)piperidin-2-one

https://huagongshe.com/reaction/594625

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-BromopropaneHCID 7840—
Reactant6-(2,6-Dimethoxyphenyl)-1-(4-hydroxybenzyl)piperidin-2-oneHCID 69081744—
Product6-(2,6-Dimethoxyphenyl)-1-(4-propoxybenzyl)piperidin-2-oneHCID 69085230—

Reaction Steps

Prepared according to the described general procedure 7 (GP7) by O-alkylation of 6-(2,6-dimethoxyphenyl)-1-(4-hydroxybenzyl)piperidin-2-one with commercially available 1-bromopropane. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.79 min.; [M+H]+: 384.19 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-25725d019ea04503bcdbcc1b23725575
Source noteuspto-grants-2016_01