2,6-Dimethoxybenzaldehyde → HCID 69084073, compound

HRID 594642Notes

Reaction equation

HRID 594642 reaction equation
[F:1][C:2]([F:14])([F:13])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH2:12])=[CH:7][CH:6]=1.[CH3:15][O:16][C:17]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[C:18]=1[CH:19]=O>>[CH3:15][O:16][C:17]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[C:18]=1[CH:19]1[N:12]([CH2:11][C:8]2[CH:7]=[CH:6][C:5]([O:4][CH2:3][C:2]([F:13])([F:14])[F:1])=[CH:10][CH:9]=2)[C:5](=[O:4])[CH2:6][CH2:7][CH2:8]1

Participants

3

Reactant 2

HCID 964042,6-DimethoxybenzaldehydeHCID 16227862(4-(2,2,2-Trifluoroethoxy)phenyl)methanamine

Product 1

HCID 69084073HCID 69084073, compound

Procedure

Prepared according to the described general procedure 6 (GP6) with commercially available (4-(2,2,2-trifluoroethoxy)phenyl)methanamine and commercially available 2,6-dimethoxybenzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.80 min.; [M+H]+: 424.08 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-60882f65e4964b06bc66f9958e535bd7
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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