4-Methylsulfonylbenzylamine → 6-(2,6-Dimethoxyphenyl)-1-(4-(methylsulfonyl)benzyl)piperidin-2-one

HRID 594644Notes

Reaction equation

HRID 594644 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH2:12])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH3:13][O:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[C:16]=1[CH:17]=O>>[CH3:13][O:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[C:16]=1[CH:17]1[N:12]([CH2:11][C:8]2[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6][CH:7]=2)[C:15](=[O:14])[CH2:16][CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 574214-MethylsulfonylbenzylamineHCID 964042,6-Dimethoxybenzaldehyde

Product 1

HCID 690816496-(2,6-Dimethoxyphenyl)-1-(4-(methylsulfonyl)benzyl)piperidin-2-one

Procedure

Prepared according to the described general procedure 6 (GP6) with commercially available (4-(methylsulfonyl)phenyl)methanamine and commercially available 2,6-dimethoxybenzaldehyde. Subsequent purification by preparative HPLC the target compound. LC-MS (conditions E): tR=0.65 min.; [M+H]+: 404.07 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC the target compound

Sources & evidence

ORD record
ord-05ba2306fcdf439da4e7eac948c71fc9
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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