4-(Trifluoromethoxy)benzylamine → HCID 69082711, compound

HRID 594648Notes

Reaction equation

HRID 594648 reaction equation
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH2:11])=[CH:6][CH:5]=1.[F:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[C:16]=1[CH:17]=O.[Na].C(OCC)(=O)[CH2:27][C:28]([C:30](OCC)=[O:31])=[O:29]>>[F:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[C:16]=1[CH:17]1[N:11]([CH2:10][C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:12])([F:13])[F:1])=[CH:9][CH:8]=2)[C:30](=[O:31])[CH:28]([OH:29])[CH2:27]1

Participants

4

Reactant 3

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 27373572-Fluoro-6-methoxybenzaldehydeHCID 57351814Diethyl 2-oxosuccinate,sodium salt

Product 1

HCID 69082711HCID 69082711, compound

Procedure

Prepared according to general procedure 10A (GP10A) and general procedure 10B (GP10B) using commercially available (4-(trifluoromethoxy)phenyl)methanamine, commercially available 2-fluoro-6-methoxybenzaldehyde, and commercially available diethyl oxalacetate sodium salt. LC-MS (conditions A): tR=0.80 min.; [M+H]+: 400.22 g/mol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fb725614441c4d00bb8c8f390f94b4f2
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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