HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Phenyl-1,3-thiazole-4-carbaldehyde → 6-(4,6-Dimethoxypyrimidin-5-yl)-1-((2-phenylthiazol-4-yl)methyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Phenyl-1,3-thiazole-4-carbaldehyde | HCID 736524 | — |
| Reactant | Methyl 5-amino-5-(4,6-dimethoxypyrimidin-5-yl)pentanoate | HCID 69082521 | — |
| Product | 6-(4,6-Dimethoxypyrimidin-5-yl)-1-((2-phenylthiazol-4-yl)methyl)piperidin-2-one | HCID 69085180 | — |
Reaction Steps
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(4,6-dimethoxypyrimidin-5-yl)pentanoate with commercially available 2-phenylthiazole-4-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.77 min.; [M+H]+: 410.79 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-09d2e4e677904e85a2e35aa4a31d76bc |
| Source note | uspto-grants-2016_01 |