HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Phenylbenzaldehyde → 1-([1,1'-Biphenyl]-3-ylmethyl)-6-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Phenylbenzaldehyde | HCID 121053 | — |
| Reactant | Methyl 5-amino-5-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pentanoate | HCID 69095861 | — |
| Product | 1-([1,1'-Biphenyl]-3-ylmethyl)-6-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperidin-2-one | HCID 69081934 | — |
Reaction Steps
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pentanoate with commercially available [1,1′-biphenyl]-3-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.91 min.; [M+H]+: 400.01 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-ea9c722c3533448180892f394d65b09a |
| Source note | uspto-grants-2016_01 |