HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Methyl-1,3-thiazol-4-yl)benzaldehyde → 7-(3,5-Dimethoxypyridin-4-yl)-1-(3-(2-methylthiazol-4-yl)benzyl)azepan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Methyl-1,3-thiazol-4-yl)benzaldehyde | HCID 7127782 | — |
| Reactant | Methyl 6-amino-6-(3,5-dimethoxypyridin-4-yl)hexanoate | HCID 69085562 | — |
| Product | 7-(3,5-Dimethoxypyridin-4-yl)-1-(3-(2-methylthiazol-4-yl)benzyl)azepan-2-one | HCID 69082784 | — |
Reaction Steps
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(3,5-dimethoxypyridin-4-yl)hexanoate with commercially available 3-(2-methylthiazol-4-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.59 min.; [M+H]+: 438.09 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-76157216418d4daabb318b913829ce11 |
| Source note | uspto-grants-2016_01 |