2-Phenyl-1,3-thiazole-4-carbaldehyde → 7-(3,5-Dimethoxypyridin-4-yl)-1-((2-phenylthiazol-4-yl)methyl)azepan-2-one

HRID 594658Notes

Reaction equation

HRID 594658 reaction equation
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][N:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=O.[C:21]1([C:27]2[S:28][CH:29]=[C:30]([CH:32]=O)[N:31]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH3:20][O:19][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([O:17][CH3:18])[C:11]=1[CH:2]1[N:1]([CH2:32][C:30]2[N:31]=[C:27]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[S:28][CH:29]=2)[C:7](=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 7365242-Phenyl-1,3-thiazole-4-carbaldehydeHCID 69085562Methyl 6-amino-6-(3,5-dimethoxypyridin-4-yl)hexanoate

Product 1

HCID 690838057-(3,5-Dimethoxypyridin-4-yl)-1-((2-phenylthiazol-4-yl)methyl)azepan-2-one

Procedure

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(3,5-dimethoxypyridin-4-yl)hexanoate with commercially available 2-phenylthiazole-4-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.61 min.; [M+H]+: 423.86 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-5ba3fad937f649b19bf48edb3ba07d29
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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