HCID 69083292, compound → HCID 69081808, compound

Participants

Reaction Steps

A mixture of 6-(2-hydroxy-6-methoxy-3-nitrophenyl)-1-(quinolin-2-ylmethyl)piperidin-2-one (340 mg; 0.83 mmol), and 10% Pd(C) (34 mg; 10% in mass) in anh. MeOH (15 ml) was stirred at rt, under hydrogen atmosphere (1 atm), for 5.5 h. Filtration over a pad of celite, concentration to dryness under reduced pressure, and additional drying under HV afforded 6-(3-amino-2-hydroxy-6-methoxyphenyl)-1-(quinolin-2-ylmethyl)piperidin-2-one as a red solid (302 mg; 96%). LC-MS (conditions A): tR=0.41 min.; [M+H]+: 378.38 g/mol.

Provenance & Evidence