Benzaldehyde, 4-(phenylmethoxy)- → 1-(4-(Benzyloxy)benzyl)-5-(2,6-dimethoxyphenyl)pyrrolidin-2-one

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Reaction Steps

1-(4-(benzyloxy)benzyl)-5-(2,6-dimethoxyphenyl)pyrrolidin-2-one was prepared according to the described general procedure 2 (GP2) by reaction of methyl 4-amino-4-(2,6-dimethoxyphenyl)butanoate (400 mg; 1.38 mmol) with commercially available 4-(benzyloxy)benzaldehyde (293 mg; 1.38 mmol). Subsequent purification by preparative HPLC afforded 1-(4-(benzyloxy)benzyl)-5-(2,6-dimethoxyphenyl)pyrrolidin-2-one (316 mg; 55%). LC-MS (conditions A): tR=0.91 min.; [M+H]+: 417.76 g/mol.

Provenance & Evidence