反应详情

A mixture of 1-(4-(benzyloxy)benzyl)-5-(2,6-dimethoxyphenyl)pyrrolidin-2-one (316 mg; 0.75 mmol), and 10% Pd(C) (90 mg) in anh. MeOH (4 ml) was stirred at rt, under hydrogen atmosphere (1 atm), for 24 h. Filtration over a pad of celite, concentration to dryness under reduced pressure, and additional drying under HV afforded 5-(2,6-dimethoxyphenyl)-1-(4-hydroxybenzyl)pyrrolidin-2-one as a colorless solid (120 mg; 48%). LC-MS (conditions A): tR=0.67 min.; [M+H]+: 328.10 g/mol.

1. filtrationFiltration
2. concentrationover a pad of celite, concentration to dryness under reduced pressure
3. customadditional drying under HV