3-(2-Methyl-1,3-thiazol-4-yl)benzaldehyde → 6-([1,1'-Biphenyl]-2-yl)-1-(3-(2-methylthiazol-4-yl)benzyl)piperidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	3-(2-Methyl-1,3-thiazol-4-yl)benzaldehyde	HCID 7127782	—
Reactant	Methyl 5-([1,1'-biphenyl]-2-yl)-5-aminopentanoate	HCID 69083690	—
Product	6-([1,1'-Biphenyl]-2-yl)-1-(3-(2-methylthiazol-4-yl)benzyl)piperidin-2-one	HCID 69080987	—

Reaction Steps

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-([1,1′-biphenyl]-2-yl)-5-aminopentanoate with commercially available 3-(2-methylthiazol-4-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.95 min.; [M+H]+: 439.10 g/mol.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09242970B2
Source dataset	uspto-grants-2016_01
ORD ID	ord-45c9389bb49a4187b7029abb31b85a04
Source note	uspto-grants-2016_01